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Ketamine is a medication that is used to induce loss of consciousness, or anesthesia. It can produce relaxation and relieve pain in humans, animals and many more.
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Psychiatric side effects are frequent as well as raised blood pressure and nausea. Liver and urinary toxicity are common among regular users of high doses of ketamine for recreational purposes. Ketamine is an NMDA receptor antagonist, and that accounts for most of its actions except the antidepressive effect, the mechanism of which is a matter of much research and debate.
Ketamine was discovered in 1956 and approved for use in the United States in 1970. It was extensively used for surgical anesthesia in the Vietnam War due to its safety. Ketamine is also used as a recreational drug for its hallucinogenic and dissociative effects. Ketamine is on the World Health Organization’s List of Essential Medicines. and is available as a generic medication
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Ketamine is a medication that is used to induce loss of consciousness, or anesthesia. It can produce relaxation and relieve pain in humans and animals.
It is a class III scheduled drug and is approved for use in hospitals and other medical settings as an anesthetic.
However, it is also a commonly abused “recreational” drug, due to its hallucinogenic, tranquilizing and dissociative effects.
Controversy has arisen about using ketamine “off-label” to treat depression. Off-label uses of drugs are uses that are not approved by the the United States, (U.S.) Food and Drug Administration (FDA).
Ketamine is safe to use in controlled, medical practice, but it has abuse potential. Used outside the approved limits, its adverse mental and physical health effects can be hazardous. Prolonged use can lead to tolerance and psychological addiction.
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At anesthetic doses, 10–20% of adults (1–2% of children) experience adverse psychiatric reactions that occur during emergence from anesthesia, ranging from dreams and dysphoria to hallucinations and emergence delirium. These can be counteracted by pretreating with a benzodiazepine or propofol. Ketamine anesthesia commonly causes tonic–clonic movements (greater than 10% of people) and rarely hypertonia. Vomiting can be expected in 5–15% of the patients; pre-treatment with propofol mitigates it as well. Laryngospasm occurs only rarely with ketamine. Ketamine, generally, stimulates breathing; however, in the first 2–3 minutes of a high-dose rapid intravenous injection it may cause a transient respiratory depression.
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Ketamine is sometimes used in the treatment of status epilepticus that has failed to adequately respond to standard treatments, although only limited evidence (case studies and no randomized controlled trials) exists in its favor.
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Ketamine Hydrochloride Injection USP is a rapid-acting, non-barbiturate general anesthetic. It produces an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes and normal or slightly enhanced skeletal muscle tone. Mild cardiac stimulation and occasionally respiratory depression occur.
The anesthetic state produced by Ketamine Hydrochloride Injection USP has been termed “dissociative anesthesia” in that it appears to selectively interrupt association pathways of the brain before producing somesthetic sensory blockage. Ketamine Hydrochloride Injection USP decreases the activity of the neocortex and subcortical structures (thalamus) and increases the activity in the limbic system and
Following administration of recommended doses of Ketamine Hydrochloride Injection USP, blood pressure and pulse rate are usually moderately and temporarily increased. In 12,283 procedures, the median systolic rise was 24% and the median diastolic rise was 22%. Ketamine is given only by or under the immediate supervision of a medical doctor trained to use it. If you will be receiving ketamine during surgery, your doctor or anesthesiologist will give you the medicine and closely follow your progress. UK Ketamine supplier, Hydrocodone Store UK.
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