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Active substance: Hydromorphone hydrochloride (Extended Release)

Brand names: Dilaudid

Quantity: 100 Tablets

Strength: 8 mg



Dilaudid 8 mg – This medication contains hydromorphone in a long-acting form. It is used to help relieve severe ongoing pain (such as due to cancer). Hydromorphone belongs to a class of drugs known as opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain.Do not use the extended-release form of hydromorphone to relieve pain that is mild or that will go away in a few days. This medication is not for occasional (“as needed”) use.

The objective of this open-label, randomized, two-period crossover study was to compare the oral bioavailability of a Mallinckrodt test tablet formulation of hydromorphone 8 mg to an equivalent oral dose of a commercially available Dilaudid 8 mg tablet (DILAUDID® 8 mg, Knoll Pharmaceutical Company) in a test group of healthy subjects under fasting conditions.

DOSAGE Dilaudid 8 mg

Dosage for severe pain

Adult dosage (ages 18–64 years)

Oral tablet: Typical starting dosage is 2–4 mg once every 4–6 hours.

Extended-release oral tablet: This form of the drug is only used in people who are taking at least 60 mg of morphine, 30 mg of oral oxycodone, or 8 mg of oral Dilaudid 8 mg per day. Your doctor will tell you what dosage of hydromorphone you should take. They may increase your dosage by 4–8 mg every 3–4 days if needed.

Child dosage (ages 0–17 years)

This medication has not been studied in children. It should not be used in people younger than 18 years.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects. Your doctor may start you on a lowered dosage or a different schedule. This can help keep levels of this drug from building up too much in your body.


Symptoms of an overdose include the following:

  1. Slow or difficult breathing

  2. Muscle twitches or spasms

  3. Pinpoint pupils

  4. Lightheadedness or loss of consciousness

  5. Clammy skin

  6. Confusion

  7. Coma

  8. Weak heart beat

  9. Weakness or fatigue

Missed Dose of Dilaudid 8 mg

If you miss a dose of Dilaudid 8 mg and are taking it on a regular schedule, take your missed dose as soon as you remember.

However, if it’s almost time for the next dose, skip the missed dose and continue on your regular dosing schedule. Don’t double up on doses to make up for a missed one.


More common side effects

The more common side effects of this drug can include:

  1. lightheadedness

  2. dizziness

  3. drowsiness

  4. nausea

  5. vomiting

  6. sweating

  7. flushing (reddening and warming of your skin)

  8. euphoria (a feel-good effect)

  9. dry mouth

  10. itching

If Dilaudid 8 mg these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. if Dilaudid 8 mg your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

Heart problems. Symptoms can include:

  1. very fast or slow heart rate

  2. faster pulse

  3. chest pain

  4. Eye or vision changes. Symptoms can include:

  5. trouble seeing or blurry vision

  6. double vision

  7. small pupils that look like pinpoints

  8. Stomach problems. Symptoms can include:

  9. constipation

  10. stomach pain

  11. bowel blockage, which can cause:

  12. nausea

  13. vomiting

  14. inability to pass gas or stool

Nervous system and muscle problems. Dilaudid 8 mg Symptoms can include:
  1. headache

  2. tremors (involuntary muscle movements)

  3. unusual or involuntary movement of your eyes

  4. strange or prickling sensation on your skin

  5. Mood or behavior changes. Symptoms can include:

  6. agitation

  7. nervousness

  8. anxiety

  9. depression

  10. hallucinations (seeing or hearing something that isn’t there)

  11. disorientation

  12. trouble sleeping

  13. strange dreams

  14. Blood pressure changes. Symptoms can include:

  15. flushing

  16. high or low blood pressure

  17. Adrenal insufficiency. Symptoms can include:

  18. long-lasting tiredness

  19. muscle weakness

  20. pain in your abdomen

  21. Androgen deficiency. Symptoms can include:

  22. tiredness

  23. trouble sleeping

  24. decreased energy

  25. Extreme drowsiness

Trouble breathing or shortness of breath


Interactions that increase your risk of side effects of Dilaudid 8 mg

Increased side effects of hydromorphone: Taking hydromorphone with certain medications raises your risk of side effects. Examples of these drugs include:

Benzodiazepines such as lorazepam, clonazepam, and diazepam: Taking this Dilaudid 8 mg with hydromorphone may cause breathing problems, a drop in blood pressure, and extreme drowsiness. It can also cause coma or death.

General anesthetics such as propofol, midazolam, and etomidate:

So Taking these drugs with hydromorphone may cause breathing problems, a drop in blood pressure, and extreme drowsiness. Dilaudid 8 mg may also cause a coma.

Prochlorperazine, promethazine, and chlorpromazine:

Taking these drugs with hydromorphone may cause breathing problems, a drop in blood pressure, and extreme drowsiness. It may also cause a coma.

Monoamine oxidase inhibitors (MAOIs) such as phenelzine, tranylcypromine, isocarboxazid, and selegiline:

MAOIs can greatly increase your risk of hydromorphone toxicity. So (having dangerous levels of the drug in your body). The use of hydromorphone is not recommended because if you take MAOIs or within 14 days of stopping treatment with an MAOI.

Anticholinergic drugs such as diphenhydramine, solifenacin, tolterodine, and benztropine:

Taking these drugs with but hydromorphone can cause urinary retention (trouble passing urine), severe constipation, and bowel blockage.

Increased side effects from other Dilaudid 8 mg: Taking hydromorphone with certain medications raises your risk of side effects from those drugs. Examples of these drugs include:

Serotonergic drugs, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs): Taking these drugs with hydromorphone may cause serotonin syndrome, which can be fatal. Symptoms can include agitation, sweating, muscle twitches, and confusion.

Interactions that can make your drugs less effective

When you take hydromorphone with certain Dilaudid 8 mg, it may not work as well to treat your condition. This is because the amount of hydromorphone in your body may be decreased. Examples of these drugs include:

Pentazocine, nalbuphine, butorphanol, and buprenorphine: Taking these drugs with hydromorphone can also cause symptoms of opioid withdrawal if you’ve been taking hydromorphone for a long time.

Disclaimer Dilaudid 8 mg

Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the Dilaudid 8 mg information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgment of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient.

responsibility does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, Dilaudid 8 mg interactions, allergic reactions, or adverse effects. So If you have questions about the substances because you are taking, check with your doctor, nurse, or pharmacist.


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100 Tablets


8 mg


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